Journal
VIROLOGY
Volume 396, Issue 2, Pages 264-271Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.virol.2009.10.024
Keywords
PRRSV; Dendritic cells; Foxp3; IL-10; TGF-beta
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Funding
- P.N. CICYT [AGL2006-13809-C02-01, CSD 2006-00007]
- SEP-CCNACyT [82850]
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The aim of this study was to characterize the immune responses of DCs after infection with four different EU Strains of PRRSV and whether they show any ability to immunomodulate T cells activation. Our results show that all EU strains can efficiently infect and replicate in DCs. Nevertheless, SLA-II levels remained unaltered in DC infected by all EU PRRSV strains, whereas SLA-I expression was only reduced when strain 2992 was used. IL-10 production was induced by three EU PRRSV strains, being strain 2992 the highest inducer. However, no induction of Treg cells, measured by CD25 and Foxp3 expression on lymphocytes co-cultured with infected DCs, was found. TGF-beta induction was not detected in DC infected with any EU strain tested. In conclusion, DCs infected with EU PRRSV strains exhibited an unbalanced ability to stimulate T cell response and was strain dependent. However, Treg cells were not induced, at least in vitro. (C) 2009 Elsevier Inc. All rights reserved.
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