Journal
VIROLOGY
Volume 384, Issue 2, Pages 317-323Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.virol.2008.10.005
Keywords
Small DNA tumor viruses; Ubiquitin-proteasome pathway; E3 ligase
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Funding
- Canadian Cancer Society through the National Cancer Institute of Canada
- Canadian Institutes of Health Research
- Biotechnology and Biological Sciences Research Council [BBS/E/I/00001191] Funding Source: researchfish
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Viruses have evolved to use cellular pathways to their advantage, including the ubiquitin-proteasome pathway of protein degradation. In several cases, viruses produce proteins that highjack cellular E3 ligases to modify their substrate specificity in order to eliminate unwanted cellular proteins, in particular inhibitors of the cell cycle. They can also inhibit E3 ligase to prevent specific protein degradation or even use the system to control the level of expression of their own proteins. In this review we explore the specific ways that small DNA tumor viruses exploit the ubiquitin-proteasome pathway for their own benefit. (C) 2008 Elsevier Inc. All rights reserved.
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