Journal
VIROLOGY
Volume 387, Issue 2, Pages 459-465Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.virol.2009.03.001
Keywords
Hendra virus; Nipah virus; Animal model; Immunoprophylaxis; Emergent disease; Pathogenesis
Categories
Funding
- Aventis Pharma
- Bayer Pharma
- ANR (MIME)
- INSERM
- Malaysian Government IRPA [06-002-03-0000PR-0060/04]
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Hendra virus (HeV) and Nipah virus (NiV) are recently-emerged, closely related and highly pathogenic paramyxoviruses. We have analysed here the pathogenesis of the acute HeV infection using the new animal model, golden hamster (Mesocricetus auratus), which is highly susceptible to HeV infection. HeV-specific RNA and viral antigens were found in multiple organs and virus was isolated from different tissues. Dual pathogenic mechanism was observed: parenchymal infection in various organs, including the brain, with vasculitis and multinucleated syncytia in many blood vessels. Furthermore, monoclonal antibodies specific for the NiV fusion protein neutralized HeV in vitro and efficiently protected hamsters from HeV if given before infection. These results reveal the similarities between HeV and NiV pathogenesis, particularly in affecting both respiratory and neuronal system. They demonstrate that hamster presents a convenient novel animal model to Study HeV infection, opening new perspectives to evaluate vaccine and therapeutic approaches against this emergent infectious disease. (C) 2009 Elsevier Inc. All rights reserved,
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