Journal
VIROLOGY
Volume 384, Issue 1, Pages 28-32Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.virol.2008.11.044
Keywords
Avian influenza viruses
Categories
Funding
- Chinese National Natural Science Foundation [30825032]
- Chinese National Key Basic Research Program (973) [2005CB523005, 2005CB523200]
- Chinese National S and T Plan [2006BAD06A05]
- Specially Promoted Research
- Research Centers for Emerging and Reemerging Infectious Diseases
- Ministry of Education, Culture, Sports, Science and Technology of Japan
- Public Health Service research
- National Institute of Allergy and Infectious Diseases
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A/duck/Guangxi/53/2002 (DKGX/53) and A/duck/Fujian/01/2002 (DKFJ/01) are H5N1 avian influenza viruses that are lethal in chickens. In mice, however, DKFJ/01 is highly pathogenic, whereas DKGX/53 displays low pathogenicity. In this study, we used reverse genetics to demonstrate that two amino acid residues at positions 30 and 215 of the M1 protein of these two viruses are important determinants for pathogenicity in mice. We thus firstly prove the M1 protein contributes to the virulence of H5N1 viruses in mice, and the amino acid residues shown to attenuate the virulence could be targeted in influenza virus candidates for live vaccine development. (C) 2008 Elsevier Inc. All rights reserved.
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