Journal
VIROLOGY
Volume 384, Issue 2, Pages 266-273Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.virol.2008.09.027
Keywords
Polyomavirus; JCV; BKV; PML; Polyomavirus nephropathy; KI; WU; MCV
Categories
Funding
- NIH [AI060584, CA118970]
- American Heart Association [0825806G]
- F.G. Novy Fellowship
- NCI [T32-CA009676]
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The human polyomaviruses, BK virus and JC virus, have long been associated with serious diseases including polyomavirus nephropathy and progressive multifocal leukoencephalopathy. Both viruses establish ubiquitous, persistent infections in healthy individuals. Reactivation can occur when the immune system is impaired, leading to disease progression. Recently, the human polyomavirus family has expanded with the identification of three new viruses (KI, WU and Merkel cell polyomavirus), all of which may prove to be involved in human disease. This review describes the general aspects of human polyomavirus infections and pathogenicity. Current topics of investigation and future directions in the field are also discussed. (C) 2008 Elsevier Inc. All rights reserved.
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