Journal
VIROLOGY
Volume 394, Issue 1, Pages 8-11Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.virol.2009.08.040
Keywords
Human papillomavirus; Recombination; Variant
Categories
Funding
- National Cancer Institute [CA84396]
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Intratypic diversity of human papillomavirus (HPV) genome is generally characterized by point mutation, insertion, and/or deletion. Using PCR-based cloning and sequencing, we detected concurrent infection with 8 HPV16 variants in a woman enrolled in the ASCUS-LSIL Triage Study. The European variant was the major variant: each of the 7 minor variants had partial DNA sequences identical to the European variant and another part identical to the African 2 variant. At a follow-up visit, only an HPV16 African 2 variant was detected. Results from the present Study Suggest presence Of intratypic recombination of HPV genome in natural infection. (C) 2009 Elsevier Inc. All rights reserved.
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