Journal
VIROLOGY
Volume 372, Issue 2, Pages 221-232Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.virol.2007.11.008
Keywords
virus budding; enveloped virus assembly; virus exit; late domain; ESCRT pathway
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Funding
- Howard Hughes Medical Institute Funding Source: Medline
- NIAID NIH HHS [R01 AI023173-23, R01 AI023173, R37 AI020201, R56 AI020201, R01 AI020201, AI-20201, R01 AI020201-26, AI-23173] Funding Source: Medline
- NIGMS NIH HHS [T32 GM008152, GM-08152] Funding Source: Medline
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Many enveloped viruses complete their replication cycle by forming vesicles that bud from the plasma membrane. Some viruses encode late (L) domain motifs that are able to hijack host proteins involved in the vacuolar protein sorting (VPS) pathway, a cellular budding process that gives rise to multivesicular bodies and that is topologically equivalent to virus budding. Although many enveloped viruses share this mechanism, examples of viruses that require additional viral factors and viruses that appear to be independent of the VPS pathway have been identified. Alternative mechanisms for virus budding could involve other topologically similar process such as cell abscission, which occurs following cytokinesis, or virus budding could proceed spontaneously as a result of lipid microdomain accumulation of viral proteins. Further examination of novel virus-host protein interactions and characterization of other enveloped viruses for which budding requirements are currently unknown will lead to a better understanding of the cellular processes involved in virus assembly and budding. (c) 2007 Elsevier Inc. All rights reserved.
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