Journal
VIROLOGY
Volume 381, Issue 1, Pages 1-5Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.virol.2008.07.039
Keywords
HIV-astrocyte; Lysosomotropic agents; HIV-reservoir
Categories
Funding
- NIH [R01 NS050064, P01 MH070306]
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We report in this study that minimum productive HIV infection in astrocytes (a predominant cell type in brain and persists for the entire life) occurs through endocytosis. The lysosomotropic agent chloroquine enhanced permissiveness of astrocyres to HIV infection possibly by circumventing degradation of endosome-entrapped viral particles. In particular, chloroquine may promote establishment of a stable long term viral reservoir in astrocyres and may eventually facilitate early onset of neurological complications. (C) 2008 Elsevier Inc. All rights reserved.
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