Journal
VIROLOGY
Volume 377, Issue 2, Pages 308-318Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.virol.2008.04.028
Keywords
bluetongue virus; BTV; Orbivirus; reovirus; full-genome sequence analysis; BTV-8
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Funding
- Biotechnology and Biological Sciences Research Council [BBS/E/I/00000999] Funding Source: researchfish
- Biotechnology and Biological Sciences Research Council [BBS/E/I/00000999] Funding Source: Medline
- Wellcome Trust Funding Source: Medline
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During 2006 the first outbreak of bluetongue ever recorded in northern Europe started in Belgium and the Netherlands, spreading to Luxemburg, Germany and north-east France. The virus overwintered (2006-2007) reappearing during May-June 2007 with greatly increased severity in affected areas, spreading further into Germany and France, reaching Denmark, Switzerland, the Czech Republic and the UK. Infected animals were also imported into Poland, Italy, Spain and the UK. An initial isolate from the Netherlands (NET2006/04) was identified as BTV-8 by RT-PCR assays targeting genome segment 2. The full genome of NET2006/04 was sequenced and compared to selected European isolates, South African vaccine strains and other BTV-8 strains, indicating that it originated in sub-Saharan Africa. Although NET2006/04 showed high levels of nucleoticle identity with other 'western' BTV strains, it represents a new introduction and was not derived from the BTV-8 vaccine, although its route of entry into Europe has not been established. (C) 2008 Elsevier Inc. All rights reserved.
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