Journal
VIROLOGY
Volume 373, Issue 1, Pages 181-188Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.virol.2007.10.040
Keywords
rhesus cytomegalovirus; alpha chemokine; CXC chemokine; U(L)b '; sequence diversity; human cytomegalovirus; UL146
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Funding
- NCRR NIH HHS [RR000169, P51 RR000169-47, P51 RR000169, P51 RR000169-48] Funding Source: Medline
- NIAID NIH HHS [R01 AI049342-08, R01 AI063356-04, AI063356, AI49342, R01 AI049342, R01 AI063356-05, R01 AI057840-04, R01 AI063356, R56 AI049342, R01 AI057840] Funding Source: Medline
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A recent comparison of two rhesus cytomegalovirus (RhCMV) genomes revealed that the region at the right end of the U-L genome component (U(L)b') undergoes genetic alterations similar to those observed in serially passaged human cytomegalovirus (HCMV). To determine the coding content of authentic wild-type RhCMV in this region, the U(L)b' sequence was amplified from virus obtained from naturally infected rhesus macaques without passage in vitro. A total of 24 open reading frames (ORFs) potentially encoding > 99 amino acid residues were identified, 10 of which are related to HCMV ORFs and 15 to previously listed RhCMV ORFs. In addition, the analysis revealed a cluster of three novel alpha chemokine-like ORFs, bringing the number of predicted alpha chemokine genes in this region to six. Three of these six genes exhibit a high level of sequence diversity, as has been observed for the HCMV alpha chemokine gene UL146. (C) 2007 Published by Elsevier Inc.
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