Journal
VIROLOGY
Volume 374, Issue 2, Pages 229-233Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.virol.2008.01.029
Keywords
HIV-1; Env sequence length; N-linked glycosylation sites; transmission; primary infection
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Funding
- NIAID NIH HHS [R01 AI058894, P01 AI057005-04, R37 AI047734, AI47734, P01 AI057005-03, R37 AI047734-09, P30 AI027757-17S39012, P01 AI057005-02, R01 AI058894-03, R01 AI055336, R37 AI047734-06A1, R01 AI058894-02, AI27757, R01 AI047734, R37 AI047734-07, P30 AI027757-169012, R01 AI049109, P01 AI057005-05, R01 AI058894-04, R01 AI058894-01, P30 AI027757, AI55336, R37 AI047734-08, P01 AI057005, P01 AI057005-010001, AI57005, P01 AI057005-01, AI49109, P01 AI057005-010002] Funding Source: Medline
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Whether there is selection for specific viral Env variants upon HIV-1 transmission is controversial. We examined the V1V2 and V1V4 regions of Env in 10 new and 8 previously described transmission pairs infected with HIV-1 subtype B, including a total of 9 pairs in which the infecting partner had developed substantial viral diversity prior to transmission. We found that during transmission of HIV-1 subtype B, as well as for other subtypes reported in the past, viral populations in recipients undergo substantial genetic bottlenecks, as well as weak evidence for a propensity to replicate viruses with shorter variable loops and fewer potential N-linked glycosylation sites. (c) 2008 Elsevier Inc. All rights reserved.
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