Journal
VIROLOGY
Volume 380, Issue 1, Pages 21-25Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.virol.2008.07.017
Keywords
cyclin-dependent kinase; human papillomaviruses; retinoblastoma tumor suppressor; centrosome duplication
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Funding
- PHS [R01 CA066980, T32CA009031]
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The human papillomavirus (HPV) E7 oncoprotein has been shown to associate with cyclin/CDK2 complexes. Here we present evidence that HPV E7 Proteins can associate with cyclin A/CDK2 and cyclin E/CDK2 complexes in cells that lack retinoblastoma tumor suppressor family members through sequences outside of the core retinoblastoma tumor suppressor binding site. Moreover, we show that HPV16 E7 can directly associate with cyclin A/CDK2 and cyclin E/CDK2 complexes. These results suggest that cyclin/CDK2 complexes may be components of HPV E7-associated cellular complexes that do not contain retinoblastoma tumor suppressor family members. (C) 2008 Elsevier Inc. All rights reserved.
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