Journal
VIROLOGY
Volume 373, Issue 1, Pages 163-170Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.virol.2007.11.018
Keywords
adenovirus; mouse adenovirus; natural killer cell; NK cell; immunodepletion; brain
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Funding
- NIAID NIH HHS [T32 AI007528, R01 AI023762-19, R01 AI023762-18, R01 AI023762-16, R01 AI023762, R01 AI023762-15, R01 AI023762-17] Funding Source: Medline
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Natural killer (NK) cells contribute to the initial nonspecific response to viral infection, and viruses exhibit a range of sensitivities to NK cells in vivo. We investigated the role of NK cells in infection of mice by mouse adenovirus type 1 (MAV-1) using antibody-mediated depletion and knockout mice. MAV-1 causes encephalomyelifis and replicates to highest levels in brains. NK cell-depleted mice infected with MAV-1 showed brain viral loads 8-20 days p.i. that were similar to wild-type control non-depleted mice. Mice genetically deficient for NK cells behaved similarly to wild-type control mice with respect to brain viral loads and survival. We conclude that NK cells are not required to control virus replication in the brains of MAV-1-infected mice. (C) 2007 Elsevier Inc. All rights reserved.
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