Journal
AUSTRALIAN PRESCRIBER
Volume 38, Issue 2, Pages 41-43Publisher
NATL PRESCRIBING SERVICE LTD
DOI: 10.18773/austprescr.2015.015
Keywords
acamprosate; alcohol dependence; baclofen; disulfiram; naltrexone; topiramate
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Drug therapy for alcohol dependence should only be used in conjunction with a comprehensive treatment plan. Naltrexone and acamprosate have well established efficacy and are first-line treatments. Naltrexone is recommended for patients aiming to cut down their alcohol intake who do not have severe liver disease or an ongoing need for opioids. Acamprosate is recommended for those who have achieved and wish to maintain abstinence. Disulfiram is no longer considered first-line treatment due to difficulties with compliance and toxicity. Although baclofen and topiramate have evidence of benefit, they are not registered for alcohol dependence and should only be considered in specialist practice.
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