Journal
VETERINARY RECORD
Volume 165, Issue 13, Pages 373-376Publisher
BMJ PUBLISHING GROUP
DOI: 10.1136/vr.165.13.373
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Serial blood samples were collected from three dwarf Friesian foals to examine their endogenous growth hormone (GH) profiles, and the integrity of the GH-insulin-like growth factor-I (IGF-I) axis was tested in one of them by examining its responses to the administration of GH-releasing hormone (GHRH) and to 10 days of treatment with recombinant equine GH. The basal serum concentrations of IGF-I in the three dwarf foals were compared with those in nine age-matched normal foals. All the dwarf foals secreted endogenous GH. Stimulation with 7.0 mu g/kg GHRH led to a 1400 per cent increase in plasma GH concentration in the dwarf foal tested, and 10 daily subcutaneous treatments with 20 mu g/kg recombinant equine GH led to a 100 per cent increase in its serum IGF-I concentration. The basal serum concentrations of IGF-I in the dwarf foals were not significantly different from those of the normal foals.
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