Journal
VETERINARY PATHOLOGY
Volume 48, Issue 4, Pages 817-822Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/0300985810382093
Keywords
feline SRY; ovotestes; XY disorder of sexual development; XY sex reversal; XY true hermaphrodite
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Funding
- NIH-NCRR [R24 RR0016094]
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Investigation of abnormal sexual development in companion animals can allow for the elimination of inherited disorders from breeding populations while contributing to the understanding of the complex process of mammalian sexual development and differentiation. A 1-year-old mixed-breed cat, presented for neutering, was tentatively diagnosed as a male with bilateral cryptorchidism. During surgery, the surgeon identified gonads in an ovarian position and a complete bicornuate uterus. Both testicular and ovarian architecture in the gonads and Mullerian and Wolffian duct derivatives were identified histologically. The karyotype was that of a normal male (38,XY), and no causative mutation was identified in the feline SRY coding sequence amplified from genomic DNA. All features of the case were compatible with a diagnosis of SRY-positive 38,XY sex reversal, true hermaphrodite phenotype. To the authors' knowledge, this is the first report of this disorder in a domestic cat.
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