Journal
VETERINARY PATHOLOGY
Volume 46, Issue 6, Pages 1275-1280Publisher
SAGE PUBLICATIONS INC
DOI: 10.1354/vp.08-VP-0226-C-FL
Keywords
Cox-2; female dogs; mammary gland; microvessel density; neoplasia
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Funding
- CAPES (Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior)
- CNPq (Conselho Nacional de Desenvolvimento e Pesquisa)
- FAPEMIG (Fundacao de amparo a pesquisa do Estado de Minas Gerais)
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Mammary tumors are among the most common neoplastic processes in female dogs. Prostaglandin E2, the catalytic product Of Cox-2, may promote tumor development and angiogenesis. It has been investigated in several human cancers and also correlated with the evolution of the disease. However, the clinical Implications Of tumor pathology require more investigation in veterinary medicine. Angiogenesis is essential for the growth and metastasis or major solid tumors and has been correlated With Prognosis In human and canine breast cancer. The aim of this study was to evaluate Cox-2 expression and microvessel density in canine mammary carcinomas and to correlate them with overall survival of the animal. Cox-2 and angiogenesis were assessed by immunohistochemistry in 46 mammary carcinomas (19 ductal and 27 metaplastic) and in healthy mammary glands. To assess tumor angiogenesis, microvessel density (MVD) was determined by CD31 staining. Immunostaining revealed that 46/46 (100%) of the tumors were positive for Cox-2 and CD31, and there was no statistical difference among tumor types. Cox-2 protein expression correlated positively with CD31 staining (r = 0.3742, P = .0104) but did not correlate significantly with tumor type. Longer overall survival was observed in metaplastic carcinomas (P = .028), in tumors with low microvessel density (P = .0002) and with low Cox-2 score (P = .01). Our results demonstrate that increased microvessel density and increased Cox-2 expression were linearly related in the canine mammary tumors Studied and were also related to worse prognosis and shorter overall survival. This Suggests that Cox-2 inhibitors could be an alternative for the treatment and control of advanced neoplastic mammary disease in female dogs.
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