Journal
VETERINARY PARASITOLOGY
Volume 201, Issue 3-4, Pages 223-225Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.vetpar.2014.02.015
Keywords
Afoxolaner; Dogs; Ixodes scapularis; Ticks; Oral
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Funding
- Merial Limited
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Efficacy of afoxolaner, a novel isoxazoline insecticide/acaricide, against Ixodes scapularis was evaluated in a laboratory study. One day prior to treatment, beagle dogs (n = 16) were infested with 50 unfed wild adult ticks. Repeat infestations were performed weekly for four additional weeks. The number of live ticks remaining on each dog was determined 48 h after treatment and after each subsequent infestation. A single oral treatment with a dose approaching the minimum effective dose of afoxolaner (2.5 mg/kg) eliminated the pre-existing infestations of I. scapularis ticks and controlled weekly re-infestations, with efficacy between 98% and 100% recorded until Day 23 and 94% at Day 30. (C) 2014 The Authors. Published by Elsevier B.V.
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