Journal
VETERINARY PARASITOLOGY
Volume 204, Issue 3-4, Pages 323-329Publisher
ELSEVIER
DOI: 10.1016/j.vetpar.2014.05.040
Keywords
Octadecanoic acid-3,4-tetrahydrofuran diester; S. scabiei var. Cuniculi; Pathologic histology; Enzyme activities
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Funding
- National Natural Science Foundation of China [31272612, 31372477]
- Doctoral Program of Higher Education Research Fund [20105103110001]
- Sichuan Youth Science and Technology Innovation Research Team for waterfowl disease prevention and control [2013TD0015]
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Octadecanoic acid-3,4-tetrahydrofuran diester, isolated from neem (Azadirachta indica) oil, exhibited potent acaricidal activity against Sarcoptes scabiei var. cuniculi. In this paper, the acaricidal mechanism of octadecanoic acid-3,4-tetrahydrofuran diester against Sarcoptes scabiei var. cuniculi was evaluated based on pathologic histology and enzyme activities. The results showed that after compound treatment for 24 h at a concentration of 20 mg/mL, the lesions of mites were prominent under transmission electron microscopy. The lesions consisted of the lysis of dermis cell membranes and cell nuclear membranes, mitochondrial morphological abnormalities, the drop of spinal disorders, and mitochondrial vacuolization. The activity of superoxide dismutase (SOD), peroxidase (POD), glutathione-s-transferases (GSTs), and Ca2+-ATPase of mites significantly changed after treatment with octadecanoic acid-3,4-tetrahydrofuran diester compared with the control group. The activities of SOD, POD, and Ca2+-ATPase were significantly suppressed, whereas that of GSTs was activated. These results indicated that the mechanism of the acaricidal activity of octadecanoic acid-3,4-tetrahydrofuran diester was mainly achieved through interference with the energy metabolism of mites, thus resulting in insect death. (C) 2014 Elsevier B.V. All rights reserved.
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