Journal
VETERINARY OPHTHALMOLOGY
Volume 12, Issue 3, Pages 192-204Publisher
WILEY-BLACKWELL
DOI: 10.1111/j.1463-5224.2009.00694.x
Keywords
canine; degeneration; gene therapy; model; neuroprotection; retina
Categories
Funding
- Foundation Fighting Blindness Individual Investigator Award
- center grants
- Fight for Sight Nowak family grant
- University of Pennsylvania Research Foundation
- NATIONAL EYE INSTITUTE [R01EY017549] Funding Source: NIH RePORTER
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Inherited retinal degenerations (RDs) are a common cause of blindness in dogs and in humans. Over the past two decades numerous genes causally associated with these diseases have been identified and several canine models have been used to improve our understanding of the molecular mechanisms of RDs, as well as to test the proof of principle and safety of novel therapies. This review briefly summarizes the drug delivery approaches and therapeutic strategies that have been and are currently tested in dogs, with a particular emphasis on corrective gene therapy, and retinal neuroprotection.
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