Journal
VETERINARY MICROBIOLOGY
Volume 169, Issue 1-2, Pages 67-73Publisher
ELSEVIER
DOI: 10.1016/j.vetmic.2013.12.015
Keywords
Variant RHDV; Young rabbits; Spain; Epizootiology
Categories
Funding
- INTERCUN
- Portuguese Foundation for Science and Technology (FCT) [PTDC/BIA-ANM/3963/2012, FCT-ANR/BIA-BIC/0043/2012]
- FCT [SFRH/BPD/73512/2010]
- North Portugal Regional Operational Programme (ON.2 - O Novo Norte) under the National Strategic Reference Framework (NSRF), through the European Regional Development Fund (ERDF)
- Fundação para a Ciência e a Tecnologia [PTDC/BIA-ANM/3963/2012] Funding Source: FCT
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Rabbit hemorrhagic disease outbreaks in young rabbits have been recently observed in Spain. In this study we have tracked the spread of variant RHDV in samples collected from rabbit farms over a period of more than one year using RT-PCR and antigen-capture ELISA. The isolates were sequenced and compared to classic and variant RHDV strains and phylogenetic analyses were conducted. Mortalities have been observed in kits as young as 11 days. More than 50% of the dead rabbits had been previously vaccinated against RHDV using commercially available inactivated vaccines indicating a putative lack of protection against the variant RHDV. The large majority of the studied outbreaks (94.5%) in Spanish farms during 2012 were due to variant RHDV and only 3 out of the 55 farms were affected by classic RHDV. The data demonstrates that the variant RHDV has spread through a large number of Spanish provinces in a relatively short period of time, largely replacing the previously predominant G1 RHDV genotypes. Considering the lack of efficient vaccines against the variant RHDV strains strict disease control and greater vigilance measures should be put in place. (C) 2013 Elsevier B.V. All rights reserved.
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