Journal
VETERINARY MICROBIOLOGY
Volume 167, Issue 1-2, Pages 159-167Publisher
ELSEVIER
DOI: 10.1016/j.vetmic.2013.08.003
Keywords
Papillomavirus; Bovine papillomavirus; Equine sarcoid; Equine genital cancers
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The Papillomaviridae family comprises a large number of viruses that can infect a broad range of hosts including mammals, birds and reptiles giving rise to benign lesions of the skin or mucosal membranes. They are characterized by great genetic diversity yet adhere to common biological principles. In this review, we first describe the structure and function of the viral proteins encoded by papillomaviruses (PVs), with a particular emphasis on bovine papillomaviruses (BPV). We then discuss the role of BPV types 1 and 2 in the pathogenesis of equine sarcoids and present recent evidence implicating a novel equine papillomavirus (EcPV-2) in the pathogenesis of equine genital cancers. (C) 2013 Elsevier B.V. All rights reserved.
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