Journal
VETERINARY MICROBIOLOGY
Volume 153, Issue 3-4, Pages 274-284Publisher
ELSEVIER
DOI: 10.1016/j.vetmic.2011.05.041
Keywords
Salmonella; Type III secretion system; Salmonella pathogenicity island-2; Subunit vaccine; Poultry
Categories
Funding
- Natural Sciences and Engineering Research Council of Canada (NSERC)
- Bioniche Life Sciences Inc.
- NSERC Associate Industrial Research Chair in food and water safety vaccines
- Saskatchewan Health Research Foundation (SHRF)
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Several structural components of the type III secretion systems (T3SS) encoded by Salmonella pathogenicity island (SPI)-1 and SPI-2 are exposed to the host's immune system prior to/during the infection/invasion process, making them potential vaccine candidates. In this study we evaluated whether chickens vaccinated with SPI-2 T3SS components could mount a significant humoral immune response (as measured by serum IgG titres) and whether these antibodies could be transferred to progeny (as measured by egg yolk IgG titres), and whether vaccinates and progeny of vaccinates could be protected against challenge with SE. The results of our studies show that vaccinated chickens do produce high levels of SPI-2 T3SS specific serum IgG that they are able to transfer to their progeny. It was demonstrated that vaccinates and progeny of vaccinates had lower overall countable recovered Salmonella enterica subspecies enterica serovar Enteritidis (SE) per bird in most situations. (C) 2011 Elsevier B.V. All rights reserved.
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