Journal
VETERINARY MICROBIOLOGY
Volume 137, Issue 3-4, Pages 408-411Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.vetmic.2009.01.036
Keywords
Pythiosis; Pythium insidiosum; Fungus-like; Terbinafine; Broth microdilution; Antifungal activity
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We evaluated the in vitro activities of terbinafine alone and in combination with amphotericin B, fluvastatin, rifampicin, metronidazole or ibuprofen against 17 clinical isolates of Pythium insidiosum. The assays were based on technique M38-A2, as well as the checkerboard microdilution method. The main synergism observed was by combination of terbinafine plus amphotericin B (41.18%). Antagonisms were observed in combinations of terbinafine with fluvastatin (35.30%) or rifampicin (5.88%). (C) 2009 Elsevier B.V. All rights reserved.
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