Journal
VETERINARY JOURNAL
Volume 187, Issue 1, Pages 23-32Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.tvjl.2010.01.018
Keywords
Porcine circovirus type 2 (PCV2); Post-weaning multisystemic wasting syndrome (PMWS); Epidemiology; Diagnosis; Control
Categories
Funding
- The Spanish Government [GEN2003-20658-C05-02]
- European Commission [513928]
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Post-weaning multisystemic wasting syndrome (PMWS) emerged as a significant disease affecting pig production in the 1990s although the causal agent, porcine circovirus type 2 (PCV2), and the disease itself, had existed in swine for many years prior to this. The important multifactorial 'triggers' of PMWS include the immune and infection status of the sow, the timing of PCV2 infection, variations in the virulence of PCV2, co-infections, immune modulation as well as host genetics and management factors. In terms of diagnosis, histopathological examination and the detection of PCV2 within lymphoid tissue remains the 'gold standard' as quantitative PCR techniques are currently not specific or sensitive enough. The recent commercial availability of PCV2 vaccines provides an excellent tool for reducing the impact of PMWS and other porcine circovirus-related diseases. This review assesses recent advances in the epidemiology, diagnosis and control of PMWS. (C) 2010 Elsevier Ltd. All rights reserved.
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