Journal
VETERINARY JOURNAL
Volume 187, Issue 3, Pages 356-362Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.tvjl.2009.12.020
Keywords
Proteome; Saliva; Porcine; Two-dimensional electrophoresis; Mass spectrometry; lmmunoblotting; Biomarkers
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Funding
- Department of Animal Medicine and Surgery of The University of Murcia, Spain [HA-2008-0016]
- Department of Biomedical Sciences, The University of Veterinary Medicine, Vienna, Austria [HA-2008-0016]
- Spanish Ministry of Education and Science [AGL 2006-05701]
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Saliva contains a number of proteins that may be useful as biomarkers of health and disease and can be easily obtained from large numbers of animals in a non-invasive, stress-free way. The objective of this study was to explore the protein composition of porcine saliva from 10 specific pathogen free pigs using first one-dimensional SOS-PAGE and then two-dimensional electrophoresis and mass spectrometry. A reference proteome pattern for porcine saliva was established with the identification of 13 different, mainly saliva-specific, proteins. These reference data will facilitate the investigation of salivary proteins potentially altered in disease and could serve as novel diagnostic biomarkers. (C) 2009 Elsevier Ltd. All rights reserved.
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