Journal
VETERINARY JOURNAL
Volume 188, Issue 3, Pages 356-358Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.tvjl.2010.05.020
Keywords
Dopamine; Dopamine transporter (DAT); Dog brain; I-123-FP-CIT; Single photon emission computed tomography
Categories
Funding
- Ghent University [BOF 07/24J/152]
Ask authors/readers for more resources
Single photon emission computed tomography (SPECT) with the cocaine-analogue [I-123]-FP-CIT is widely used for in vivo assessment of the dopamine transporter (DAT) availability. Dopaminergic disturbance has been implicated in neurological and behavioural disorders in humans and animals. Ten healthy dogs were scanned at three different time points (between 3 h and 6 h post-tracer injection) under general anaesthesia (1.4% isoflurane). A pseudo-equilibral state was reached 3-6 h after tracer injection with normal reference values for the DAT binding indices (mean +/- SD) of 15.39 +/- 2.38 (left) and 15.23 +/- 2.23 (right). By determining the pseudo-equilibrium and the normal DAT binding indices of normally behaving dogs, this study paves the way for future research on the relationship between abnormal canine behaviour and a disturbed dopaminergic system. (C) 2010 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available