Journal
VETERINARY JOURNAL
Volume 179, Issue 1, Pages 25-37Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.tvjl.2007.07.011
Keywords
Ivermectin; Pharmacokinetics; Animal species; Absorption; Distribution; Metabolism; Excretion; Cattle; Sheep; Goal; Pig; Dog; Review
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The pharmacokinetic properties of drugs are closely related to their pharmacological efficacy. The kinetics of ivermectin are characterised, in general terms, by a slow absorption process, a broad distribution in the organism, low metabolism, and slow excretion. The kinetics vary according to the route of administration, formulation, animal species, body condition, age, and physiological status, all of which contribute to differences in drug efficacy. Characterisation of ivermectin kinetics can be used to predict and optimise the value of the parasiticide effects and to design programmes for parasite control. This article reviews the pharmacokinetics of ivermectin in several domestic animal species. (c) 2007 Elsevier Ltd. All rights reserved.
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