Journal
VETERINARY JOURNAL
Volume 178, Issue 1, Pages 126-129Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.tvjl.2007.06.002
Keywords
Bovine spongiform encephalopathy; Stress; Glia; Prion; Pathogenesis; Mouse model
Categories
Funding
- Spanish Ministry of Science and Technology (MCyT) [ET2002-05168, RTA2006-00091]
Ask authors/readers for more resources
An immunohistochemical study was performed to evaluate the stress-related proteins heat shock protein 25 (HSP25) and metallothionein 1 + 2 (MT1 + 2) in the brains of a murine model of bovine spongiform encephalopathy (BSE). Transgenic mice (BoTg110) expressing the bovine cellular prion protein were intracerebrally inoculated with brainstem homogenate from BSE infected cattle. PrPBSE deposits were found in the brain as early as 150 days post-inoculation (dpi) and in mice sacrificed terminally at 290-320 dpi. Glial proliferation and spongiform change were associated with an increase in glial immunostaining of MT1 + 2 and HSP25, respectively. These proteins are associated with oxidative stress and heavy metal metabolism, which may have a role in the pathogenesis of BSE. (C) 2007 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available