Journal
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY
Volume 159, Issue 3-4, Pages 202-207Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.vetimm.2014.02.017
Keywords
Adaptive immunity; Innate immunity; T-cell; B-cell; PRRSV; Cholera toxin; Mucosal immunity
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Funding
- NIAID NIH HHS [T32 AI083196] Funding Source: Medline
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In veterinary animal species, vaccines are the primary tool for disease prevention, a key tool for treatment of infection, and essential for helping maintain animal welfare and productivity. Traditional vaccine development by trial-and-error has achieved many successes. However, effective vaccines that provide solid cross-protective immunity with excellent safety are still needed for many diseases. The path to development of vaccines against difficult pathogens requires recognition of uniquely evolved immunological interactions of individual animal hosts and their specific pathogens. Here, general principles that currently guide veterinary immunology and vaccinology research are reviewed, with an emphasis on examples from swine. Advances in genomics and proteomics now provide the community with powerful tools for elucidation of regulatory and effector mechanisms of protective immunity that provide new opportunities for successful translation of immunological discoveries into safe and effective vaccines. (C) 2014 Elsevier B.V. All rights reserved.
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