Journal
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY
Volume 142, Issue 3-4, Pages 219-227Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.vetimm.2011.05.019
Keywords
Chicken; Genetic lines; Heterophil function; beta-Glucan; Ascorbic acid; Corticosterone
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Funding
- National Research Initiative through USDA National Institute of Food and Agriculture (NIFA) [2007-35604-17866]
- USDA [2005-38420-15810]
- Royal Thai Government
- Iowa State University Center for Integrated Animal Genomics
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The effect of dietary supplementation of immunomodulators on in vitro chicken heterophil function was investigated using three diverse genetic lines of chickens (broiler, Fayoumi, and Leghorn). Dietary supplementation with beta-glucan, ascorbic acid, and corticosterone was fed from 8 to 11 weeks of age. Heterophil function was evaluated weekly during supplementation using phagocytosis, bacterial killing, and heterophil extracellular traps (HETs)-DNA release. Fayoumis fed the basal diet had significantly higher HETs-DNA release (P=0.002) than Leghorns and broilers. Both genetic line and immunomodulator diet supplementation had significant effects on bacterial killing (line and diet effect: P<0.001) and HETs-DNA release (line: P<0.001; diet: P=0.043). Dietary supplementation with immunomodulators, therefore, shows potential to affect and augment heterophil function in chickens. The current results also suggest the important role of genetics in innate immune responses. (C) 2011 Elsevier B.V. All rights reserved.
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