Journal
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY
Volume 140, Issue 3-4, Pages 199-206Publisher
ELSEVIER
DOI: 10.1016/j.vetimm.2010.12.004
Keywords
Astaxanthin; Immunity; Canine; Antioxidant
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Funding
- P&G Pet Care, Lewisburg, OH
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No information is available on the possible role of astaxanthin on immune response in domestic canine. Female Beagle dogs (9-10 mo old; 8.2 +/- 0.2 kg body weight) were fed 0, 10, 20 or 40 mg astaxanthin daily and blood sampled on wk 0, 6, 12, and 16 for assessing the following: lymphoproliferation, leukocyte subpopulations, natural killer (NK) cell cytotoxicity, and concentrations of blood astaxanthin, IgG. IgM and acute phase proteins. Delayed-type hypersensitivity (DIM) response was assessed on wk 0, 12 and 16. Plasma astaxanthin increased dose-dependently and reached maximum concentrations on wk 6. Dietary astaxanthin enhanced DTH response to vaccine, concanavalin A-induced lymphocyte proliferation (with the 20 mg dose at wk 12) and NK cell cytotoxic activity. In addition, dietary astaxanthin increased concentrations of IgG and 104, and B cell population. Plasma concentrations of C reactive protein were lower in astaxanthin-fed dogs. Therefore, dietary astaxanthin heightened cell-mediated and humoral immune response and reduced DNA damage and inflammation in dogs. Published by Elsevier B.V.
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