Journal
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY
Volume 125, Issue 1-2, Pages 1-7Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.vetimm.2008.04.007
Keywords
BLV; sheep; cattle; lymphocyte; cell dynamics
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Funding
- European Union [INCA LSHC-CT-2005-018704]
- Belgian Foundation against Cancer
- Bekales Foundation
- Fonds national de la recherche scientifique (FNRS)
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Bovine leukemia virus (BLV) is a deltaretrovirus that infects and induces accumulation of B-lymphocytes in the peripheral blood and lymphoid tissues of cattle, leading to leukemia/lymphoma. BLV can also be experimentally transmitted to sheep, in which disease appears earlier and at higher frequencies. Abnormal accumulation of leukemic B-lymphocytes results from an alteration of different parameters that include cell proliferation and death as well as migration to lymphoid tissues. Interestingly, B lymphocyte turnover is increased in BLV-infected sheep but reduced in cattle, revealing a potential relationship between cell kinetics and disease progression. (C) 2008 Elsevier B.V. All rights reserved.
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