4.2 Article

Aging in the Canine and Feline Brain

Journal

Publisher

W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.cvsm.2014.07.008

Keywords

beta-Amyloid; Cat; Dog; Cognitive dysfunction; Neuron loss; Tau

Funding

  1. National Institute on Aging of the National Institutes of Health [R01AG031764, R01NS073661, P40-02512]
  2. Ara Parseghian Medical Research Foundation

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Aging dogs and cats show neurodegenerative features that are similar to human aging and Alzheimer disease. Neuropathologic changes with age may be linked to signs of cognitive dysfunction both in the laboratory and in a clinic setting. Less is known about cat brain aging and cognition and this represents an area for further study. Neurodegenerative diseases such as lysosomal storage diseases in dogs and cats also show similar features of human aging, suggesting some common underlying pathogenic mechanisms and also suggesting pathways that can be modified to promote healthy brain aging.

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