Journal
VETERINARY CLINICS OF NORTH AMERICA-SMALL ANIMAL PRACTICE
Volume 38, Issue 1, Pages 167-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.cvsm.2007.10.002
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Funding
- NIA NIH HHS [AG12694, R01 AG012694, R01 AG012694-05, R37 AG012694] Funding Source: Medline
- NATIONAL INSTITUTE ON AGING [R01AG012694, R37AG012694] Funding Source: NIH RePORTER
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Decline in cognitive functions that accompany aging in dogs may have a biologic basis, and many of the disorders associated with aging in dogs may be mitigated through dietary modifications that incorporate specific nutraceuticals. Based on previous research and the results of laboratory and clinical studies, antioxidants may be one class of nutraceutical that provides benefits to aged dogs. Brains of aged dogs accumulate oxidative damage to proteins and hpids, which may lead to dysfunction of neuronal cells. The production of free radicals and lack of increase in compensatory antioxidant enzymes may lead to detrimental modifications to important macromolecules within neurons. Reducing oxidative damage through food ingredients rich in a broad spectrum of antioxidants significantly improves, or slows the decline of, learning and memory in aged dogs.
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