Journal
CHINESE MEDICINE
Volume 10, Issue -, Pages -Publisher
BMC
DOI: 10.1186/s13020-015-0051-z
Keywords
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Funding
- Innovation and Technology Fund [ITS/262/09FP]
- Innovation and Technology Commission, Government of Hong Kong Special Administrative Region
- Seed Funding Programme for Basic Research, the University of Hong Kong [201211159146]
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Background: Erxian decoction (EXD) is used to treat menopause-related symptoms in Chinese medicine. This study aims to identify the bioactive compounds and potential actions of EXD by network pharmacological analysis. Methods: Two databases, the Traditional Chinese Medicine Systems Pharmacology database and TCM Database@Taiwan, were used to retrieve literature of phytochemicals of EXD. STITCH 4.0 and the Comparative Toxicogenomics Database were used to search for compound-protein and compound-gene interactions, respectively. DAVID Bioinformatics Resources 6.7 and Cytoscape 3.01 with Jepetto plugin software were used to perform a network pharmacological analysis of EXD. Results: A total of 721 compounds were identified in EXD, of which 155 exhibited 2,656 compound-protein interactions with 1,963 associated proteins determined by STITCH4.0 database, and of which 210 had 14,893 compound-gene interactions with 8,536 associated genes determined by Comparative Toxicogenomics Database. Sixty three compounds of EXD followed the Lipinski's Rule with OB >= 30% and DL index >= 0.18, of which 20 related to 34 significant pathway-or 12 gene-associated with menopause. Conclusions: Twenty compounds were identified by network pharmacology as potential effective ingredients of EXD for relieving menopause with acceptable oral bioavailability and druggability.
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