Journal
VETERINARY AND COMPARATIVE ORTHOPAEDICS AND TRAUMATOLOGY
Volume 23, Issue 6, Pages 385-392Publisher
GEORG THIEME VERLAG KG
DOI: 10.3415/VCOT-10-01-0017
Keywords
Non-steroidal anti-inflammatory drugs; NSAID; bone healing
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The ability of non-steroidal anti-inflammatory drugs (NSAID) to inhibit bone healing has been established in experimental animal models using mice, rats, and rabbits. The mechanism of action is largely unknown but stems from prostaglandin inhibition and is likely multifactorial. In human medicine NSAID are known to prevent heterotopic ossification, however the clinical importance of their effects on bone healing remains controversial. Although a small handful of reports suggest that NSAID suppress bone healing in dogs and horses, there is little published information to direct veterinary practice in domestic species.
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