Journal
VETERINARY AND COMPARATIVE ONCOLOGY
Volume 13, Issue 2, Pages 117-123Publisher
WILEY
DOI: 10.1111/vco.12024
Keywords
bone marrow; cytopenia; dog; flow cytometry; lymphoma; staging
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Funding
- Progetti di Ricerca di Interesse Nazionale (PRIN), Ministry of Education, University and Research, Italy
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Official guidelines do not consider bone marrow (BM) assessment mandatory in staging canine lymphoma unless blood cytopenias are present. The aim of this study was to find out if blood abnormalities can predict marrow involvement in canine large B-cell lymphoma. BM infiltration was assessed via flow cytometry. No difference was found between dogs without haematological abnormalities and dogs with at least one. However, the degree of infiltration was significantly higher in dogs with thrombocytopenia, leucocytosis or lymphocytosis and was negatively correlated to platelet count and positively to blood infiltration. Our results suggest that blood abnormalities are not always predictive of marrow involvement, even if thrombocytopenia, leucocytosis or lymphocytosis could suggest a higher infiltration. BM evaluation should therefore be included in routine staging in order not to miss infiltrated samples and to improve classification. However, its clinical relevance and prognostic value are still not defined and further studies are needed.
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