Journal
VASCULAR PHARMACOLOGY
Volume 63, Issue 3, Pages 178-181Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.vph.2014.09.003
Keywords
S-nitrosothiols; Systemic sclerosis; Skin score
Categories
Funding
- Arthritis Research UK [19427, 144524, 14383]
- Versus Arthritis [19427] Funding Source: researchfish
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Objective: S-Nitrosothiols (RSNOs) are bioactive forms of nitric oxide which are involved in cell signalling and redox regulation of vascular function. Circulating S-nitrosothiols are predominantly in the form of S-nitrosoalbumin. In this study plasma concentrations of S-nitrosothiols were measured in patients with systemic sclerosis (SSc) where NO metabolism is known to be abnormal. Patients and methods: Venous blood was collected from 16 patients with Raynaud's phenomenon (RP), 45 with systemic sclerosis (SSc) (34 patients had limited SSc (IcSSc) and 11 diffuse cutaneous disease (dcSSc)). Twenty six healthy subjects were used as controls. Plasma S-nitrosothiol concentrations were measured by chemiluminescence. The measurements were related to the extent of biological age, capillary/skin scores and disease duration. Results: Plasma RSNO levels in patients with Raynaud's phenomenon (RP) and in those with SSc was significantly lower compared to the concentrations in control subjects. In SSc, plasma S-nitrosothiols were often below the level of detection (1nM). Conclusions: Low S-nitrosothiol concentrations were observed in the blood of patients with SSc and patients with RP indicating a profound disturbance of nitric oxide metabolism. (C) 2014 Elsevier Inc. All rights reserved.
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