Journal
VASCULAR PHARMACOLOGY
Volume 56, Issue 5-6, Pages 262-266Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.vph.2012.01.002
Keywords
Vasohibin; Angiogenesis
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Angiogenesis is thought to be regulated by the local balance between angiogenesis stimulators and angiogenesis inhibitors. A number of endogenous regulators of angiogenesis have been found in the body. We recently isolated vasohibin-1 (VASH1) as a negative feedback regulator of angiogenesis produced by endothelial cells, and VASH2 as a homologue of VASH1 thereafter. We found that VASH1 was expressed in endothelial cells to terminate angiogenesis, whereas VASH2 promoted angiogenesis, in the mouse model of angiogenesis. This mini-review will focus on the vasohibin family in relation to the regulation of angiogenesis. (C) 2012 Elsevier Inc. All rights reserved.
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