Journal
VASCULAR
Volume 17, Issue -, Pages S15-S20Publisher
SAGE PUBLICATIONS LTD
DOI: 10.2310/6670.2008.00089
Keywords
-
Categories
Ask authors/readers for more resources
Vascular smooth muscle cell (VSMC) differentiation is an essential component of vascular development. These cells perform biosynthetic, proliferative, and contractile roles in the vessel wall. VSMCs are not terminally differentiated and are able to modulate their phenotype in response to changing local environmental cues. There is clear evidence that alterations in the differentiated state of the VSMC play a critical role in the pathogenesis of atherosclerosis and intimal hyperplasia, as well as in a variety of other major human diseases, including hypertension, asthma, atherosclerosis and vascular aneurysms. The focus of this review is to provide an overview of the current state of knowledge of molecular mechanisms involved in controlling phenotypic switching of VSMCs, with particular focus on examination of the signaling pathways that regulate this process.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available