Journal
VACCINE
Volume 32, Issue 28, Pages 3469-3472Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2014.04.070
Keywords
Brighton Collaboration; Adverse events following immunization; Vaccine safety monitoring
Categories
Funding
- NCATS/NIH [UL1 TR000445]
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The Brighton Collaboration is a global research network focused on vaccine safety. The Collaboration has created case definitions to determine diagnostic certainty for several adverse events. Currently nested within multi-page publications, these definitions can be cumbersome for use. We report the results of a randomized trial in which the case definition for anaphylaxis was converted into a user-friendly algorithm and compared the algorithm with the standard case definition. The primary outcomes were efficiency and accuracy. Forty medical students determined the Brighton Level of diagnostic certainty of a sample case of anaphylaxis using either the algorithm or the original case definition. Most participants in both groups selected the correct Brighton Level. Participants using the algorithm required significantly less time to review the case and determine the level of diagnostic certainty [mean difference = 107s (95% CI: 13-200; p = 0.026)], supporting that the algorithm was more efficient without impacting accuracy. (C) 2014 Elsevier Ltd. All rights reserved.
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