Journal
VACCINE
Volume 32, Issue 41, Pages 5285-5289Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2014.07.083
Keywords
Influenza; Vaccine effectiveness; Influenza-like illness; China
Categories
Funding
- Beijing Science and Technology Planning Project of Beijing Science and Technology Commission [Z131100005613048]
- Capital Medical Development Research Fund
- Beijing Nova Program of the Beijing Science and Technology Commission [Z111107054511062]
- National Key Program for Infectious Disease of China [2013ZX10004218]
Ask authors/readers for more resources
Background: Influenza vaccine coverage remains low in China, and there is limited information on the preventive value of local vaccination programs. Methods: As part of influenza virological surveillance in Beijing, China during the 2012-2013 influenza season, we assessed the vaccine effectiveness (VE) of one or more doses of trivalent inactivated influenza vaccine (IIV3) in preventing medically-attended influenza-like-illness (ILI) associated with laboratory-confirmed influenza virus infection using a test-negative case-control design. Influenza vaccination was determined based on self-report by adult patients or the parents of child patients. Results: Of 1998 patients with ILI, 695 (35%) tested positive for influenza viruses, including 292 (42%) A(H3N2), 398 (57%) A(H1N1)pdm09, and 5 (1%) not (sub)typed influenza viruses. The rate of influenza vaccination among all patients was 4% (71/1998). Among influenza positive patients, 2% (57/1303) were vaccinated compared to 4% (14/695) among influenza negative patients, resulting in VE for one or more doses of vaccine (adjusted forage, sex, week, and days since illness onset) against all circulating influenza viruses of 52% (95% CI = 12-74%). A significant adjusted VE for one or more doses of vaccine for all ages against A(H1N1)pdm09 of 59% (95% Cl, 8-82%) was observed; however, the VE against A(H3N2) was 43% (95% CI, -30% to 75%). The point estimate of VE was 59% (95% CI, 19-79%) for those aged <60 years, but a negative VE point estimate without statistical significance was observed among those aged >= 60 years. Conclusions: IIV3 conferred moderate protection against medically-attended influenza in Beijing, China during the 2012-2013 season, especially against the A(H1N1)pdm09 strain and among those aged <60 years old. (C) 2014 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available