Journal
VACCINE
Volume 31, Issue 40, Pages 4280-4283Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2013.06.103
Keywords
Influenza; Influenza-like illness; Influenza vaccine; Vaccine effectiveness; Influenza season
Categories
Funding
- Victorian Government Department of Health
- Australian Government Department of Health and Ageing
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Vaccine effectiveness (VE) studies are often made for a season which may refer to different analysis periods in different systems. We examined whether the use of four different definitions of season would materially affect estimates of influenza VE using data from the Victorian general practice sentinel surveillance network for 2007-2012. In general, the choice of analysis period had little effect on VE estimates (five percentage points) when there was a statistically significant protective effect of vaccination (2007, 2010 and 2012). In contrast, for years when the analysis period varied widely depending on the method used and when VE estimates were imprecise, the change in VE estimate was as much as 43 percentage points (2008). Studies of influenza VE should clearly define the analysis period used and, where possible, provide sensitivity analyses to align this definition with other VE studies. (C) 2013 Elsevier Ltd. All rights reserved.
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