Journal
VACCINE
Volume 31, Issue 19, Pages 2403-2415Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2013.03.022
Keywords
Transcutaneous vaccination; Skin; Patch formulation; Microneedle
Categories
Funding
- National Institute of Biomedical Innovation (NIBIO)
- Ministry of Health, Labour and Welfare
- Ministry of Education, Culture, Sports, Science, and Technology of Japan [24390041, 23659079]
- Mochida Memorial Foundation for Medical and Pharmaceutical Research
- Tokyo Biochemical Research Foundation
- Grants-in-Aid for Scientific Research [24390041, 23659079] Funding Source: KAKEN
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Transcutaneous immunization (TCI) systems that use the skin's immune function are promising needle-free, easy-to-use, and low-invasive vaccination alternative to conventional, injectable vaccination methods. To develop effective TCI systems, it is essential to establish fundamental techniques and technologies that deliver antigenic proteins to antigen-presenting cells in the epidermis and dermis while overcoming the barrier function of the stratum corneum. In this review, we provide an outline of recent trends in the development of techniques for the delivery of antigenic proteins and of the technologies used to enhance TCI systems. We also introduce basic and clinical research involving our TCI systems that incorporate several original devices. (C) 2013 Elsevier Ltd. All rights reserved.
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