Journal
VACCINE
Volume 31, Issue 37, Pages 4003-4008Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2013.05.063
Keywords
Clostridium perfringens; NetB; Pore-forming toxin; Necrotic enteritis; Chicken; Vaccine
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Funding
- Wellcome Trust award [WT089618MA]
- European Union Marie Curie Network grant [237942]
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NetB (necrotic enteritis toxin B) is a recently identified beta-pore-forming toxin produced by Clostridium perfringens. This toxin has been shown to play a major role in avian necrotic enteritis. In recent years, a dramatic increase in necrotic enteritis has been observed, especially in countries where the use of antimicrobial growth promoters in animal feedstuffs has been banned. The aim of this work was to determine whether immunisation with a NetB toxoid would provide protection against necrotic enteritis. The immunisation of poultry with a formaldehyde NetB toxoid or with a NetB genetic toxoid (W262A) resulted in the induction of antibody responses against NetB and provided partial protection against disease. (C) 2013 The Authors. Published by Elsevier Ltd. All rights reserved.
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