Journal
VACCINE
Volume 31, Issue 4, Pages 711-717Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2012.11.031
Keywords
B-cell memory; Vaccination; Antibodies; ELISPOT
Categories
Funding
- GlaxoSmithKline
- International Partners Limited
- Karolinska Institutet
- Regione Autonoma della Sardegna, Cagliari, Italy
- Swedish Children Cancer Foundation
- Stiftelsen Frimurare Barnhuset i Stockholm
- Swedish Medical Society
- Stockholm County Council through the ALF
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The persistence of antigen-specific memory B-cells (MBCs) in children and young adults long time after vaccination against measles, mumps and rubella (MMR) is not known. Here we have looked at the Swedish immunization program and examined children 1-10 years after the first MMR dose in early childhood, as well as young adults 7-18 years after the second dose of MMR. We show that Ab titers and MBCs against measles and rubella have different kinetics, indicating that the MBC pool and the corresponding Ab titers are regulated independently. These data fit well with other findings that continuous IgG secretion comes from long-lived plasma cells and not MBCs. We also demonstrate that individuals with low post-vaccination Ab titers might have an adequate MBC response. It remains to be shown if memory B-cells provide the same protection as specific antibodies, but our data is a valuable complement to the incomplete knowledge about correlates of protection after vaccination. (C) 2012 Elsevier Ltd. All rights reserved.
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