Journal
VACCINE
Volume 30, Issue 31, Pages 4638-4643Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2012.04.099
Keywords
Chikungunya virus (CHIKV); O'nyong-nyong virus (ONNV); A129 mice; Interferon (IFN); Maternal-fetal immunity
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Funding
- NIH [5T32AI007536, AI082202]
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Emerging mosquito-borne alphavirus infections caused by chikungunya virus (CHIKV) or o'nyong-nyong virus (ONNV) are responsible for sporadic and sometimes explosive urban outbreaks. Currently, there is no licensed vaccine against either virus. We have developed a highly attenuated recombinant CHIKV candidate vaccine (CHIKV/IRES) that in preclinical studies was demonstrated to be safe, immunogenic and efficacious. In this study we investigated the potential of this vaccine to induce cross-protective immunity against the antigenically related ONNV. Our studies demonstrated that a single dose of CHIKV/IRES elicited a strong cross-neutralizing antibody response and conferred protection against ONNV challenge in the A129 mouse model. Moreover, CHIKV/IRES immune A129 dams transferred antibodies to their offspring that were protective, and passively transferred anti-CHIKV/IRES immune serum protected AG129 mice, independently of a functional IFN response. These findings highlight the potential of the CHIKV/IRES vaccine to protect humans against not only CHIKV but also against ONNV-induced disease. (C) 2012 Elsevier Ltd. All rights reserved.
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