Journal
VACCINE
Volume 30, Issue 51, Pages 7353-7358Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2012.04.085
Keywords
Influenza virus; Polymerase; Nucleoprotein; Nuclear import
Categories
Funding
- MRC grant [G0700848]
- MRC [G117/457, G0700848] Funding Source: UKRI
- Medical Research Council [G0700848, G117/457] Funding Source: researchfish
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Unusually for an RNA virus, influenza A viruses transcribe and replicate their genomes in the nuclei of infected cells. As a result the viral ribonucleoprotein complexes (RNPs), and their newly synthesised protein subunits, must interact with the host nuclear import machinery. In this review we discuss how the virus exploits nuclear import pathways to allow regulated and chaperoned assembly of RNPs in the nucleus, and describe how the import machinery itself can be a determinant of host tropism. (C) 2012 Elsevier Ltd. All rights reserved.
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