Journal
VACCINE
Volume 30, Issue 3, Pages 539-543Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2011.11.071
Keywords
Rotavirus; Vaccine; Case-control studies; Hospitalization; Spain
Categories
Funding
- Rotavirus Programme
- European Centre for Disease Prevention and Control (ECDC)
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Two rotavirus vaccines have been available since 2006. This study evaluates the effectiveness of these vaccines using a test-negative case-control design in Navarre, Spain. We included children 3-59 months of age who sought medical care for gastroenteritis and for whom stool samples were taken between January 2008 and June 2011. About 9% had received the pentavalent vaccine (RotaTeq) and another 8% received the monovalent vaccine (Rotarix). Cases were the 756 children with confirmed rotavirus and controls were the 6036 children who tested negative for rotavirus. Thirty-five percent of cases and 9% of controls had required hospitalization (p < 0.0001). The adjusted effectiveness of complete vaccination was 78% (95% CI: 68-85%) in preventing rotavirus gastroenteritis and 83% (95% CI: 65-93%) in preventing hospitalization for rotavirus gastroenteritis. No differences between the two vaccines were detected (p = 0.4523). Both vaccines were highly effective in preventing cases and hospital admissions in children due to rotavirus gastroenteritis. (C) 2011 Published by Elsevier Ltd.
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